Tuesday, February 19, 2013

Michael Jordan's Influence Praised By J. Cole, Kobe Bryant

J. Cole, Meek Mill and Bun B recount their favorite MJ moments and sneakers on Jordan's 50th birthday.
By Rob Markman, with additional reporting by Sway Calloway


Michael Jordan in 1989
Photo: Mike Powell/Getty Images Sport

Source: http://www.mtv.com/news/articles/1702151/michael-jordan-50th-birthday.jhtml

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Monday, February 18, 2013

Lack of iron regulating protein contributes to high blood pressure of the lungs

Feb. 17, 2013 ? A protein known to regulate iron levels in the body has an unexpectedly important role in preventing a form of high blood pressure that affects the lungs, and in stabilizing the concentration of red cells in blood, according to a study in mice by researchers at the National Institutes of Health.

In mice, lack of iron regulatory protein 1 (Irp1) results in pulmonary hypertension, a form of high blood pressure that affects the lungs, and to polycythemia, a rare disorder in which the body produces excess red blood cells.

"This insight might lead to progress in treating cases of polycythemia or pulmonary hypertension without a known cause," said senior author Tracey A. Rouault, M.D., of the Division of Intramural Research (DIR) at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), where the research was conducted. It's possible, she added, that human cases of these disorders might result from malfunctioning copies of the gene for Irp1.

The study also provides insight into how the body directs iron into the manufacture of blood to prevent anemia, the deficiency of red blood cells.

The findings appear in Cell Metabolism.

Dr. Rouault collaborated with more than a dozen other NIH researchers, including first authors Manik C. Ghosh, Ph.D., and Deliang Zhang, Ph.D., also of the NICHD's DIR, as well as researchers at the NIH Veterinary Resources Program and the National Heart, Lung and Blood Institute. Researchers from the University of Colorado School of Medicine, Denver, and the University of Nebraska-Lincoln were also part of the team.

Iron regulatory protein 1 (Irp1) detects iron levels in cells and directs either the storage or use of iron, depending on other conditions in the body. The researchers found that mice lacking Irp1 produced high levels of hypoxia inducible factor 2-alpha (HIF2 alpha), a protein produced in response to low oxygen conditions, like those that occur at high altitudes. In turn, HIF2 alpha spurs production of the hormone erythropoietin, which stimulates the production of red blood cells.

When the animals were put on low-iron diets, they did not become anemic, but instead developed polycythemia and pulmonary hypertension.

In people, polycythemia and high blood pressure in the lungs are rare conditions, and in some cases occur without a known cause. It is possible that changes in the gene for Irp1 may account for some of these cases, the researchers suggest.

To investigate Irp1's role in regulating the body's use of iron, the researchers reared mice lacking the gene that makes Irp1 and divided the animals into two groups, feeding one group a normal diet and the other a low iron diet.

Within a year, less than 40 percent of the mice on the low-iron diet had survived. Most had died from abdominal hemorrhaging. The researchers found that the mice on low iron diets had high levels of HIF2 alpha in the lungs and kidney. These animals produced high levels of erythropoietin, which resulted in polycythemia. HIF2 alpha also triggered increased production of a substance known as endothelin-1 in the lungs, which likely contributed to the development of pulmonary hypertension.

"Irp1 appears to be the switch that controls whether HIF2 alpha protein is made," Dr. Zhang said.

This research also provided insight into how Irp1 functions under normal circumstances Dr. Rouault explained. The researchers theorize that in low-iron conditions, Irp1 allows the production of HIF2 alpha. HIF2 alpha then triggers production of erythropoietin, to generate more red blood cells. To supply iron for the red blood cells, iron is removed from the tissues. When tissue iron levels decline too much, Irp1 halts production of HIF2 alpha, and production of new blood cells ceases, conserving the body's remaining iron stores. Production of red blood cells then declines, leading to anemia.

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The above story is reprinted from materials provided by NIH/National Institute of Child Health and Human Development (NICHD).

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Manik?C. Ghosh, De-Liang Zhang, Suh?Young Jeong, Gennadiy Kovtunovych, Hayden Ollivierre-Wilson, Audrey Noguchi, Tiffany Tu, Thomas Senecal, Gabrielle Robinson, Daniel?R. Crooks, Wing-Hang Tong, Kavitha Ramaswamy, Anamika Singh, Brian?B. Graham, Rubin?M. Tuder, Zu-Xi Yu, Michael Eckhaus, Jaekwon Lee, Danielle?A. Springer, Tracey?A. Rouault. Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2?. Cell Metabolism, 2013; 17 (2): 271 DOI: 10.1016/j.cmet.2012.12.016

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/fFp2oFXIYx4/130217165414.htm

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Proposed assault weapons ban would protect more than 2,200 firearms

One model of the Ruger .223 caliber Mini-14 is on the proposed list to be banned, while a different model is on a list of exempted firearms. Both hold dozens of rounds of ammunition. 'What a joke,' says a former FBI agent wounded in a bank robbery shoot-out.

By Eileen Sullivan,?Associated Press / February 17, 2013

This undated evidence photo shows the Ruger Mini?14 used in the deadly 1986 bank robbery shootout in Miami that left two FBI agents dead and five others injured. New models of this firearm that have folding stocks and pistol grips would be banned under proposed gun control legislation. But a similar model without a folding stock would be exempted. Both models can take detachable magazines that hold dozens of rounds of ammunition.

FBI/AP

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Congress' latest crack at a new assault weapons ban would protect more than 2,200 specific firearms, including a semi-automatic rifle that is nearly identical to one of the guns used in the bloodiest shootout in FBI history.

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One model of that firearm, the Ruger .223 caliber Mini-14, is on the proposed list to be banned, while a different model of the same gun is on a list of exempted firearms in legislation the Senate is considering. The gun that would be protected from the ban has fixed physical features and can't be folded to be more compact. Yet the two firearms are equally deadly.

"What a joke," said former FBI agent John Hanlon, who survived the 1986 shootout in Miami. He was shot in the head, hand, groin and hip with a Ruger Mini-14 that had a folding stock. Two FBI agents died and five others were wounded.

RECOMMENDED:?How much do you know about the Second Amendment? A quiz.

Hanlon recalled lying on the street as brass bullet casings showered on him. He thought the shooter had an automatic weapon.

Both models of the Ruger Mini-14 specified in the proposed bill can take detachable magazines that hold dozens of rounds of ammunition. "I can't imagine what the difference is," Hanlon said.

President Barack Obama has called for restoring a ban on military-style assault weapons and limiting the size of ammunition magazines.

A bill introduced last month by Sen. Dianne Feinstein, D-Calif. would ban 157 specific firearms designed for military and law enforcement use and exempt others made for hunting purposes. It also would ban ammunition magazines that hold more than 10 rounds.

Yet there are firearms that would be protected under Feinstein's proposal that can take large capacity magazines like the ones used in mass shootings that enable a gunman to fire dozens of rounds of ammunition without reloading.

Feinstein said in a written response to questions from The Associated Press that the list of more than 2,200 exempted firearms was designed to "make crystal clear" that the bill would not affect hunting and sporting weapons.

The December shooting at an elementary school in Newtown, Conn., that left 26 students and educators dead forced Washington to focus on curbing gun violence, a risky political move not tried in decades.

The gun industry, which is fighting any sort of ban, says gun ownership in the U.S. is the highest it's ever been, with more than 100 million firearms owners.

Obama and Vice President Joseph Biden have traveled around the country in an effort to gain support for new laws. Feinstein's proposal is the only sweeping piece of legislation designed to ban assault weapons currently being considered.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/RJAozSuCGxA/Proposed-assault-weapons-ban-would-protect-more-than-2-200-firearms

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Australia wants Israel to provide details on death of ?Prisoner X?

Australia wants Israel to provide details on death of ?Prisoner?X?

?I need to know what the contact was between Australian agencies and those of Israel, and I need to see what the Israelis want to tell Australia,? Carr stated. ?The key is to get all the information.?

??The Haaretz newspaper reported on Friday that Israel has agreed to pay millions in compensation to Zygier?s family.

A source told the newspaper that Israel agreed to pay millions of shekels several weeks ago, after an investigation concluded that Zygier?s death had been a suicide and before the affair was exposed by the Australian media?.?

Sun Feb 17, 2013 6:10AM GMT

PressTV

Australia has called on the Israeli regime to provide details about the death of an Australian-Israeli ?Mossad agent? who allegedly committed suicide in an Israeli prison in 2010.

Newspapers lead their front pages in Australia with the story of Ben Zygier, February 14, 2013.
Australian Foreign Minister Bob Carr said on Sunday that the ministry was seeking answers in a ?formal report? from the Tel Aviv regime over the circumstances surrounding the suspicious death of 34-year-old Ben Zygier known as ?Prisoner X.?

On February 12, reporter Trevor Bormann revealed on Australian Broadcasting Corporation (ABC) that the prisoner who had worked for Mossad for ten years was ?found hanged in a cell with state-of-the-art surveillance systems? near Tel Aviv in December 2010. Carr told reporters in Sydney that the Australian government had ?asked? the Israeli regime ?for a contribution to that report.?

The Australian foreign minister said Canberra wanted Tel Aviv to ?submit? an explanation of how this tragic death came about.?

?I need to know what the contact was between Australian agencies and those of Israel, and I need to see what the Israelis want to tell Australia,? Carr stated. ?The key is to get all the information.?

Following the ABC revelation, the Tel Aviv regime was forced to admit that Zygier had been jailed under a false identity ?for security reasons? despite nearly two years of Israel?s efforts to cover up the secret.

on February 14, a report by the New York Times said Zygier was among the 26 suspects in a murder plot in which Mahmoud al-Mabhouh, a Hamas official, was tracked and killed in his hotel room hours after his arrival in Dubai, the United Arab Emirates, in January 2010.

The assassins had reportedly used fake passports from Australia, Britain, Ireland, Germany and France, among other countries.

The report added that ?Prisoner X? had provided the officials in Dubai with ?names and pictures and accurate details? in exchange for protection.

However, the Israeli regime kidnapped him from his hideout and jailed him over treason nearly a month after the operation over the speculation that he had been on the verge of exposing Tel Aviv?s secrets about the passports.

DB/HSN

http://www.presstv.ir/detail/2013/02/17/289354/israel-should-explain-prisoner-x-death/

Israel Considering Making ?Prisoner X? Report Public

The Prosecution is considering making public the report which determined that ?Prisoner X? committed suicide while in prison.

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By Elad Benari

First Publish: 2/17/2013, 4:33 AM

Arutz Sheva

Ayalon jail, where Zygier was held.

Ayalon jail, where Zygier was held.

Reuters

The State Prosecutor is considering making public the report which determined that ?Prisoner X? Ben Zygier committed suicide while in prison, it was reported on Saturday night.

The report in question was authored by Justice Daphna Blatman-Kedrai, president of the Rishon Lezion Magistrate?s Court, and it concluded that the cause of Zygier?s death was suicide.

According to reports in Israeli media, the Justice Ministry is looking into ways in which to make the findings public. This could happen as soon as this week.

Last week Israel lifted parts of a gag order over the Prisoner X affair, allowing media outlets to reveal that there was indeed an Israeli citizen, who held foreign citizenship as well, and who was held in an Israeli prison under a false name.

The prisoner was given a false name for security reasons but his real family had been informed of his whereabouts. He also had lawyers who were aware of his situation.

The prisoner ?was found dead in his cell two years ago,? state sources indicated. ?One and a half months ago an investigation concluded that the death was a suicide.?

?The file was passed to the state prosecution to determine if there had been criminal negligence.?

Vice Prime Minister and Minister for Strategic Affairs Moshe Yaalon said Saturday evening that the steps taken against ?Prisoner X? were necessary in order to save lives.

?We are a unique country in terms of our security situation,? Yaalon told Channel 2?s Meet the Press.?

Asked why Zygier was arrested, he said, ?Out of considerations of pikuach nefesh [the halakhic precept that refers to the saving of lives], we needed to take such a step.

?If we reached this situation, there must have been a misstep that required steps to be taken with proper consideration and under full monitoring.?

Yaalon stressed that Zygier?s relatives in Australia and the Australian authorities were updated in real time about developments regarding Zygier.

?The state of Israel is not a dark regime. Every suicide in jail necessitates an investigation and this is what happened in this case, too. We know how to learn lessons,? said Yaalon.

The Haaretz newspaper reported on Friday that Israel has agreed to pay millions in compensation to Zygier?s family.

A source told the newspaper that Israel agreed to pay millions of shekels several weeks ago, after an investigation concluded that Zygier?s death had been a suicide and before the affair was exposed by the Australian media.

http://www.israelnationalnews.com/News/News.aspx/165309#.USCGeHYgjxY

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Source: http://nuclear-news.net/2013/02/17/australia-wants-israel-to-provide-details-on-death-of-prisoner-x/

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Sunday, February 17, 2013

Crowdfunding for Filmmakers - Complications Ensue


I keep hearing that traditional funding for indie films is getting harder and harder.

I'm not sure it was ever that easy, unless you count the moment right after video stores came in and you could put together almost any cheesy erotic thriller or teenagers-in-a-cabin-in-the-woods horror movie and make a direct-to-video movie. If you read Joe Camp's book about how he funded BENJI, the sleeper dog movie hit of 1974, he had a lot of trouble getting his movie made, and then more trouble getting it into theaters.

But word is that indie dramas are almost dead in North America; a distributor friend of mine told me not even to use the word when describing our current project. So, everybody's talking about crowdfunding.?

Raising money from individual strangers is not new. When I was at Arama Entertainment as VP of Development a ways back, we worked with these financiers from Texas who had raised a lot of money speculating on ostrich farming. They had a "boiler room" full of guys who'd call dentists and tell them how much money they could make investing in ostriches. At the time, ostrich meat was selling at a premium. The meat tastes more like steak than chicken, but it's low fat. Ranchers were buying fertilized ostrich eggs for $300, while an actual ostrich was worth, say, a couple of thousand. Dentists are people who (a) have a biggish income and (b) really boring jobs. ? Our Texas friends were offering them an investment, but they were also offering them something to dream about other than problematic teeth.

Our Texas guys could see that the ostrich boom couldn't last; eventually there would be as many ostriches in Texas as anyone would possibly want to eat. So they decided to get into show business. They raised $600,000 for us, from dentists who would invest $5000 -- an amount they could afford to lose -- and thereby buy the right to tell people at cocktail parties that they were in show business. Because who wants to hear about teeth?

The way the boiler room works is there's a bunch of guys with long lists of presumably wealthy people, and they just call and call and call until they get someone on the hook. Think Glengarry Glen Ross. The boiler room takes a pretty hefty chunk of the money it raises, and passes the rest along to the filmmaker, who spend it to make a movie. The investors rarely get a profit, but, like buying a lottery ticket, they get to dream about being in the movies.

Crowdfunding takes that idea and puts it on the Internet, with some differences. Mostly, crowdfunding is not about your contributors hoping to make a profit. They are hoping to support the arts. And, they usually get some sort of "perk," from a thank-you on someone's Twitter feed, to an Executive Producer title on the film, to a t-shirt, to what have you. I give Vermont Public Radio $90, I get a nice mug. That sort of thing.

John Trigonis crowdfunded his short CERISE, and wrote a book about it called CROWDFUNDING FOR FILMMAKERS. It is a very in-depth book about how he did it, and how to do it right.

Unfortunately, and this is not at all the book's fault, my takeaway is: ?crowdfunding is a lousy way to raise money for filmmaking. There seems to be a huge amount of effort involved for very little reward. He spent two months intensively farming his contacts in order to raise $5000. He recounts in considerable detail how other would-be filmmakers leveraged their Twitter feeds, Facebook networks, Google Plus, etc., to raise similar amounts. He talks about how he contributed to one filmmaker who, in exchange for your $33 contribution, would mail you a vinyl LP from his personal collection. Other filmmakers will send you a "personalized sound" or work your chosen word into a song.

And it's not mostly strangers. It's mostly your friends. Trigonis even posted requests for money on his friends' Facebook walls.

If you're actually in show business, I think this would be a terrible idea. If you ask your friends for money, they will ask you for money. Everybody has a project. If 20 friends give me fifty bucks each, and then I give 20 friends fifty bucks, we're just moving the money around (and paying Indiegogo a rake). More importantly, I want friendship from my friends, not money. I'm happy to help my friends out -- help them get jobs, connect them, give them advice, feed them, pour liquor into them -- but if all they wanted was money from me, I think I'd feel dissed.?

So crowdfunding involves (a) annoying the crap out of your friends (b) making it your full-time job (c) for really not all that much money.?

I have seen slightly more respectable crowdfunding campaigns, but they're still for small amounts of money. Jane Espenson raised $60,000 for her web series HUSBANDS. My agent contributed to a crowdfunding campaign from David Fincher.

But these are Famous People. I am sure that if Joss Whedon wanted to raise a hundred grand for another Dr. Horrible's Sing-Along, he could do it at the drop of a hat (and a few dozen hours of work for his assistant).?

But Joss Whedon could also write a hundred thousand dollar check without blinking, considering what he must have been paid to direct THE AVENGERS and what he will almost certainly get paid if he is interested in directing any future Avengers movies. And Jane Espenson can raise $60,000 by writing a television script.

Also, Joss Whedon can make a really great web short for a hundred thousand dollars, because what cinematographer isn't going to jump at the chance to do a favor for Joss Whedon?

I am always impressed by people who make a crowd-pleasing short for $5,000, or a film that is even releasable for $100,000. For people like that, crowdfunding is a possibility. I don't think you can count on raising anywhere near a million bucks, if that's what you need to make a professional quality movie.?

Based on this book, I feel like for most people, crowdfunding is a financing source of last resort.?

And that's not surprising. You're not asking people to invest in a film; there's no financial upside. You're asking for donations.?

That said, this is a useful book, should you decide to go for it. It will give you a good sense of how much work, and what sort of work, you'll need to do in order to get your money. If you're not sure, it will let you know what you're in for. I am going to send it to a couple of people I'm working with who have brought up crowdfunding, so at least we're all on the same page about what it entails.

Source: http://complicationsensue.blogspot.com/2013/02/crowdfunding-for-filmmakers.html

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Saturday, February 16, 2013

New Glarus' Deb Carey rubs shoulders with Obamas, Apple CEO at State of the Union address

White House Press

New Glarus Brewing Co. president Deb Carey sat next to Apple CEO Tim Cook and behind First Lady Michelle Obama at Tuesday's State of the Union address in Washington, D.C.

Wisconsin residents scanning First Lady Michelle Obama?s contingent at Tuesday night?s State of the Union address might have noticed a local face sitting next to Apple Inc. CEO Tim Cook.

Yep, that was Deb Carey, founder and president of New Glarus Brewing Co., sandwiched between Cook and Oregon Gov. John Kitzhaber, a row behind the First Lady.

Carey was part of a small group invited by the First Lady to attend the speech by President Barack Obama, including Oak Creek Police Lt. Brian Murphy, who was shot while responding to last August?s shooting at an Oak Creek Sikh temple.

Carey got the call from Michelle Obama's Feb. 8.

?It?s just really thrilling to me,? Carey told me in a phone interview Friday. ?I think it?s a great honor. It was totally unexpected. I was just going about my Friday thinking I was going to get through it and then (the call) was like a bombshell.?

Carey and her husband, Dan, the company?s master brewer, paid their way to Washington, D.C., Carey said.

It wasn?t her first time getting a special invite from the White House. Carey has visited the nation?s capital a handful of times for meetings of the White House small business council, and in November the group spoke with President Obama and Vice President Joe Biden about the fiscal cliff and challenges their small businesses face.

In 2011, Carey was named Wisconsin?s Small Business Person of the Year and the national runner-up Small Business Person of the Year by the U.S. Small Business Administration.

She called Tuesday?s atmosphere ?electric.?

?I felt privileged to be a witness because I thought the president did an excellent job of bridge building and reaching out for solutions for all of America and not being partisan,? Carey said of the State of the Union address. ?I think it?s hard for anyone to argue against correcting housing issues or creating jobs.?

Jeff Engel is The Business Journal's reporter covering the manufacturing industry and technology.

Source: http://feedproxy.google.com/~r/vertical_49/~3/cwhib0beOPs/new-glarus-deb-carey-rubs-shoulders.html

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